Statins are cholesterol-lowering drugs that are the cornerstone of primary and secondary prevention of cardiovascular disease. In recent years, the pleiotropic effects of statins have attracted attention. Statins have been shown to reduce cardiovascular events independently of baseline low-density lipoprotein (LDL) cholesterol levels and have been shown to reduce inflammatory factors such as C-reactive protein. Experimental evidence in animals indicates that statins can prevent sepsis and modulate the severity of sepsis. Two small observational studies have shown a reduction in sepsis-related mortality in statin-treated patients and a reduction in the incidence and severity of sepsis in statin-treated patients. A recent large population-based cohort study found a reduced incidence of sepsis in patients who were prescribed statins after being hospitalized for a cardiovascular event. This raises the question of whether statin therapy should be continued in critically ill patients. The current study also provides preliminary evidence for the safety of statin use in this cohort. Given that other observational data show that discontinuation of statins in current statin users is associated with the worst outcomes in patients with bacteremia, this suggests that statins should be continued in critically ill patients. Support the recommendation that However, it is important to remember that statins can be associated with life-threatening rhabdomyolysis and liver dysfunction. Particular attention should be paid to the frequency of use of concomitant medications in the ICU and in specific patient cohorts with potential adverse drug interactions. Therefore, pending the results of further clinical trials, continuation of statin therapy should be considered unless contraindicated, but careful monitoring of creatine kinase and liver function on a regular basis is important. In summary, ANZ -This important study by STATInS researchers adds important new data to the body of data on statin use in sepsis. However, more research is needed. Thus, long-term studies of high-dose statins in sepsis patients are warranted. Future studies should focus on her three cohorts of patients. Patients with established sepsis, existing statin users with severe sepsis, and statin-naïve patients at high risk of sepsis previously treated with statins. Studies must continue to be closely monitored for possible toxicity. In the meantime, with appropriate safety monitoring, continuation of previous statin use should be considered in critically ill patients with sepsis. Future studies should focus on either referral to treatment with statins of existing statin user populations with documented severe sepsis or on statin-naive patients at increased risk of severe sepsis. I have. Statin use was strongly and independently associated with a reduced risk of hospitalization for sepsis in patients with chronic kidney disease requiring dialysis. Randomized trials of statins in patients with chronic kidney disease should investigate prevention of sepsis as a potentially important benefit. Therefore, our aim was to investigate the effect of statin drug treatment on sepsis rates in a prospective cohort study of chronic kidney disease and dialysis patients. We hypothesized that statins would reduce the incidence of sepsis in these high-risk patients. This national propensity score cohort study found that statin use for at least 30 days reduced risk-adjusted in-hospital mortality by 14%. The protective effect of statins appeared to persist up to 1 year after hospital discharge. A high-potency statin reduced his risk of one-year mortality after sepsis by 20% compared with nonusers, and a low-potency statin reduced his risk by 11%.

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